Islamist-led rebels toppled Syria's longtime ruler Bashar al-Assad in a lightning offensive that a UN envoy called "a watershed moment" for the nation marred by civil war.
Here are key reactions from around the world:
China: 'Return to stability'
Beijing "is closely following the development of the situation in Syria and hopes that Syria returns to stability as soon as possible", the foreign ministry said.
France: 'Time for unity'
Welcoming Assad's ouster, France called on Syrians to "reject all forms of extremism".
"While the (Assad) regime has never ceased to pit Syrians against each other, and Syria is fractured and fragmented, the time for unity has come," foreign affairs minister spokesman Christophe Lemoine said, urging a peaceful political transition.
Germany: 'Full protection for minorities'
The country must not now fall into the hands of other radicals, whatever form they take," German Foreign Minister Annalena Baerbock said.
She urged "full protection for ethnic and religious minorities such as Kurds, Alawites or Christians" and political inclusivity.
Iran: 'Political dialogue'
In its first response to developpemnet in syria, Iran reaffirmed its steadfast and fundamental stance on respecting Syria's unity, sovereignty, and territorial integrity, the Iranian foreign ministry said in a statement.
"We emphasize that the Syrian people are the ones who determine their country's fate, free from any destructive interventions or foreign impositions," the statement read.
The ministry added that Iran will monitor development in Syria and the region closely, and will adopt appropriate approaches and positions.
Diplomats from Iran were reported to have left the embassy in Damascus before it was attacked by "unknown individuals" on Sunday, Iranian state TV said.
Their departure followed calls by Iranian Foreign Minister Abbas Araghchi on Saturday for "political dialogue" between the Syrian government and opposition groups.
Turkey: 'Country in turmoil'
Turkish Foreign Minister Hakan Fidan said the overthrow of the Assad regime was not sudden but rather the result of the grinding civil war.
"Of course, this didn't happen overnight. For the last 13 years, the country has been in turmoil," Fidan said at conference in Doha.
UAE: 'Work together'
A senior United Arab Emirates official urged Syrians to collaborate in order to avert a spiral into chaos.
"We hope that the Syrians will work together, that we don't just see another episode of impending chaos," presidential adviser Anwar Gargash said at the Manama Dialogue in Bahrain.
UK: 'Political solution'
Britain's Deputy Prime Minister Angela Rayner told Sky News that while Assad "wasn't exactly good" to the Syrian people, "we need stability in that region".
"Dictatorship and terrorism creates problems for the people of Syria, who have faced so much already," she said. "That's why we have to have a political solution where the government is acting in the interests of the Syrian people."
UN: 'Cautious hope'
The UN envoy for Syria called the rebel takeover "a watershed moment" for the country marred by nearly 14 years of civil war.
"Today we look forward with cautious hope to the opening of a new (chapter), one of peace, reconciliation, dignity and inclusion for all Syrians," special envoy Geir Pedersen said.
Trump: 'Russia not interested any longer'
US President-elect Donald Trump attributed the fall of Assad to losing the backing of Russia.
"Assad is gone," he said on his Truth Social platform. "His protector, Russia, Russia, Russia, led by Vladimir Putin, was not interested in protecting him any longer."
His comments followed an earlier statement from National Security Council spokesman Sean Savett that President Joe Biden was keeping a close eye on "extraordinary events" transpiring and remained in constant contact with regional partners.
